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Celiaki som modell för autoimmun sjukdom. Transglutaminas har nyckelroll--stressreaktion sätter fart på ond cirkel

Celiac disease as a model for autoimmune disease. Transglutaminase has the key role--stress reaction triggers the vicious circle

På svenska

Author

Summary, in English

The autoantigen of endomysial antibodies in coeliac disease has been found to be an enzyme, tissue transglutaminase. Zinc inhibits the calcium-dependent activation of this thiol enzyme and also decreases the affinity between transglutaminase and the antibodies. Physiologically, transglutaminases catalyse the formation of bridges between lysine- and glutamine-containing peptides. Theoretically, if accidentally activated, for example due to a stress-induced low concentration of intestinal zinc, tissue transglutaminase will sequentially deamidate specific glutamine residues in gliadins. During this process, an abnormally long-lived thioester intermediate between the active site cysteine of the enzyme and a previously, partly deamidated gliadine may trigger the T-cells in persons with HLA DQ2/DQ8, generating antibodies against both transglutaminase and gliadin. Furthermore, the resulting villous atrophy decreases the absorption of zinc, thus causing a vicious circle. In rheumatoid arthritis a similar pattern is observed with the formation of antibodies against citrulline as well as against the calcium-dependent citrullinating thiol-enzyme, peptidylargininedeiminase, which also is inhibited by zinc.

Department/s

Publishing year

2006

Language

Swedish

Pages

1523-1526

Publication/Series

Läkartidningen

Volume

103

Issue

19

Document type

Journal article

Publisher

Swedish Medical Association

Topic

  • Rheumatology and Autoimmunity

Keywords

  • Glutenintolerans
  • Transglutaminaser
  • Autoimmuna sjukdomar

Status

Published

Research group

  • Chronic Inflammatory and Degenerative Diseases Research Unit

ISBN/ISSN/Other

  • ISSN: 0023-7205