Ribosylurea accumulates in yeast urc4 mutants.
Author
Summary, in English
Yeast Saccharomyces (Lachancea) kluyveri urc4 mutants, unable to grow on uracil, biotransformed (14)C(2)-uracil into two labeled compounds, as detected by high performance liquid chromatography (HPLC). These two compounds could also be obtained following organic synthesis of ribosylurea. This finding demonstrates that in the URC pyrimidine degradation pathway, the opening of the uracil ring takes place when uracil is attached to the ribose moiety. Ribosylurea has not been reported in the cell metabolism before and the two observed compounds likely represent an equilibrium mixture of the pyranosyl and furanosyl forms.
Department/s
Publishing year
2010
Language
English
Pages
433-437
Publication/Series
Nucleosides, Nucleotides & Nucleic Acids
Volume
29
Issue
4-6
Document type
Journal article
Publisher
Taylor & Francis
Topic
- Biological Sciences
Status
Published
ISBN/ISSN/Other
- ISSN: 1525-7770