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Ribosylurea accumulates in yeast urc4 mutants.

Author

  • Olof Björnberg
  • M Vodnala
  • V Domkin
  • A Hofer
  • Anna Rasmussen
  • G Andersen
  • Jure Piskur

Summary, in English

Yeast Saccharomyces (Lachancea) kluyveri urc4 mutants, unable to grow on uracil, biotransformed (14)C(2)-uracil into two labeled compounds, as detected by high performance liquid chromatography (HPLC). These two compounds could also be obtained following organic synthesis of ribosylurea. This finding demonstrates that in the URC pyrimidine degradation pathway, the opening of the uracil ring takes place when uracil is attached to the ribose moiety. Ribosylurea has not been reported in the cell metabolism before and the two observed compounds likely represent an equilibrium mixture of the pyranosyl and furanosyl forms.

Publishing year

2010

Language

English

Pages

433-437

Publication/Series

Nucleosides, Nucleotides & Nucleic Acids

Volume

29

Issue

4-6

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Biological Sciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 1525-7770