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Saccharomyces kluyveri as a model organism to study pyrimidine degradation.

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Author

  • Halfdan Beck
  • Doreen Dobritzsch
  • Jure Piskur

Summary, in English

Abstract The yeast Saccharomyces kluyveri (Lachancea kluyveri), a far relative of Saccharomyces cerevisiae, is not a widely studied organism in the laboratory. However, significant contributions to the understanding of nucleic acid precursors degradation in eukaryotes have been made using this model organism. Here we review eukaryotic pyrimidine degradation with emphasis on the contributions made with S. kluyveri and how this increases our understanding of human disease. Additionally, we discuss the possibilities and limitations of this nonconventional yeast as a laboratory organism.

Publishing year

2008

Language

English

Pages

1209-1213

Publication/Series

FEMS Yeast Research

Volume

8

Issue

8

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Biological Sciences

Keywords

  • cancer
  • pyrimidine
  • nucleic acid precursors
  • structure–function relationship
  • nonconventional yeast

Status

Published

ISBN/ISSN/Other

  • ISSN: 1567-1364