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Amphiregulin acts as an autocrine survival factor for adult sensory neurons

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Author

  • Anna Nilsson
  • Martin Kanje

Summary, in English

We studied the effect of amphiregulin on axonal outgrowth and survival in sensory neurons in organ cultured and dissociated mouse dorsal root ganglia (DRG). Amphiregulin at 20 ng/ml stimulated axonal outgrowth in both preparations. The EGF receptor inhibitor AG1478 inhibited outgrowth at 10 mu M but not at 1 mu M, where it abolished the stimulatory effects of amphiregulin. Fluoro-Jade staining and neuronal counting showed that more neurons survived in culture in the presence of amphiregulin while AG1478 at 10 mu M but not 1 mu M increased cell death. Small and medium sized neurons were immunopositive for both amphiregulin and the EGF receptor. Taken together these results suggest that amphiregulin can act as an autocrine survival factor for sensory neurons and stimulate axonal outgrowth through the EGF receptor.

Publishing year

2005

Language

English

Pages

213-218

Publication/Series

NeuroReport

Volume

16

Issue

3

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Neurosciences

Keywords

  • nerve growth factors
  • sensory neurons
  • nerve regeneration
  • receptor
  • EGF
  • spinal ganglia
  • axotomy
  • axons
  • amphiregulin
  • apoptosis

Status

Published

ISBN/ISSN/Other

  • ISSN: 1473-558X