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Extinction of conditioned blink responses by cerebello-olivary pathway stimulation

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Author

Summary, in English

Learning of classically conditioned eyeblink responses depends on mechanisms within the cerebellum. It has been suggested that climbing fibres from the inferior olive transmit the unconditioned stimulus signal to the cerebellum. We have previously shown that the pathway from the deep cerebellar nuclei to the inferior olive inhibits olivary activity. It is known that repeated presentation of the conditioned stimulus on its own leads to extinction of the conditioned response. If the unconditioned stimulus signal is transmitted to the cerebellum via the inferior olive - climbing fibre system then stimulation of the nucleo-olivary pathway just before the unconditioned stimulus in a trained animal should lead to extinction. The results from this investigation confirm this.

Publishing year

2007

Language

English

Pages

1479-1482

Publication/Series

NeuroReport

Volume

18

Issue

14

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Neurosciences

Keywords

  • extinction
  • inferior olive
  • unconditioned stimulus
  • nucleo-olivary
  • eyeblink conditioning

Status

Published

Research group

  • Neural Basis of Sensorimotor Control
  • Associative Learning

ISBN/ISSN/Other

  • ISSN: 1473-558X