The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
Author
Summary, in English
The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus.
Department/s
Publishing year
2012
Language
English
Pages
412-419
Publication/Series
Nature Immunology
Volume
13
Issue
4
Links
Document type
Journal article
Publisher
Nature Publishing Group
Topic
- Cell and Molecular Biology
Status
Published
ISBN/ISSN/Other
- ISSN: 1529-2908