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A role for the fibrinogen-binding regions of streptococcal M proteins in phagocytosis resistance

På svenska

Author

  • Ulrika Ringdahl
  • Henrik Svensson
  • Heike Kotarsky
  • Maria Gustafsson
  • Maria Weineisen
  • Ulf Sjöbring

Summary, in English

All virulent group A streptococcal isolates bind fibrinogen, a property that is closely linked to expression of type-specific antiphagocytic surface molecules designated M proteins. Here we show that although the M proteins from two different strains, M1 and M5, both bind fibrinogen with high affinity, they interact with different regions in the ligand. Moreover, mapping experiments demonstrated that the fibrinogen-binding regions in the M1 and M5 proteins are quite dissimilar at the amino acid sequence level and that they bind to different regions in the plasma protein. In spite of these differences, the fibrinogen-binding regions of M1 and M5 could both be shown to contribute to streptococcal survival in human blood, providing evidence for the distinct function of a plasma protein interaction in bacterial pathogenesis.

Publishing year

2000

Language

English

Pages

1318-1326

Publication/Series

Molecular Microbiology

Volume

37

Issue

6

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Microbiology in the medical area

Status

Published

Research group

  • Neurophysiology

ISBN/ISSN/Other

  • ISSN: 1365-2958