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Thymidine kinases in archaea

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Author

  • Anders Ranegaard Clausen
  • A Matakos
  • Michael Sandrini
  • Jure Piskur

Summary, in English

Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum. The identified TK1s have high identity to Gram-positive bacteria TK1s. The TK1s from archaea, Gram-positive bacteria and eukaryotes share the same common ancestor, while the TK1s from Gram-negative bacteria belong to a less-related subgroup. It seems that a functional deoxyribonucleoside salvage pathway is not crucial for the archaeal cell.

Publishing year

2006

Language

English

Pages

1159-1163

Publication/Series

Nucleosides, Nucleotides & Nucleic Acids

Volume

25

Issue

9-11

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Biological Sciences

Keywords

  • salvage pathway
  • thymidine kinase
  • deoxyribonucleosides kinase
  • evolution
  • archaea

Status

Published

ISBN/ISSN/Other

  • ISSN: 1525-7770