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Tourniquet compression: a non-invasive method to enhance nerve regeneration in nerve grafts.

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Author

Summary, in English

One hindlimb of a rat was subjected to tourniquet compression (150, 200 and 300 mmHg; 2 h). After 6 days a 10 mm sciatic or tibial nerve graft from the compressed limb was sutured to bridge a 3-4 mm gap in the sciatic nerve of the non-compressed limb. The distances of regenerating sensory axons were measured 6 days post surgery (tibial grafts, 8 days). Compression at 200 and 300 mmHg led to significantly longer regeneration distances than those seen in controls. Incorporation of BrdU and expression of p75 receptor by non-neuronal cells (Schwann cells) in sciatic nerves 6 days after compression (150 and 300 mmHg; 2 h) was also increased as a sign of Schwann cell activation. Tourniquet compression may be used as a non-invasive method to enhance nerve regeneration in nerve grafts.

Publishing year

2002

Language

English

Pages

371-375

Publication/Series

NeuroReport

Volume

13

Issue

4

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Neurosciences

Keywords

  • Nerve Regeneration: physiology
  • Rats
  • Receptor
  • Animal
  • Female
  • Graft Survival: physiology
  • Wistar
  • Nerve Growth Factor: physiology
  • Sciatic Nerve: injuries
  • Sciatic Nerve: physiology
  • Sciatic Nerve: transplantation
  • Support
  • Non-U.S. Gov't
  • Tourniquets
  • Transplants

Status

Published

Research group

  • Hand Surgery, Malmö

ISBN/ISSN/Other

  • ISSN: 1473-558X