Nanowire Biocompatibility in the Brain - Looking for a Needle in a 3D Stack.

Summary, in English

We investigated the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry. The nanowires could be visualized in the scar by confocal microscopy (through the scattered laser light). For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain.

• Author: Cecilia Eriksson Linsmeier; Christelle Prinz; Lina Pettersson; Philippe Caroff; Lars Samuelson; Jens Schouenborg; Lars Montelius; Nils Danielsen
• Department/s: Neuronano Research Center (NRC); Solid State Physics
• Publishing year: 2009
• Language: English
• Pages: 4184-4190
• Publication/Series: Nano Letters
• Volume: 9
• Issue: 12
• Links: http://dx.doi.org/10.1021/nl902413x
• Document type: Journal article
• Publisher: The American Chemical Society (ACS)
• Topic: Nano Technology
• Status: Published
• Research group: Neuronano Research Center (NRC)
• ISBN/ISSN/Other: ISSN: 1530-6992