Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes
Author
Summary, in English
GITT showed good reproducibility and the index of insulin sensitivity derived from the GITT showed good correlation with the M-value from the euglycaemic clamp. The test also showed good discriminating capacity between individuals with varying degrees of glucose tolerance (Paper I). Both pioglitazone and insulin glargine were effective in reducing HbA1c levels in combination with other oral glucose lowering agents but pioglitazone caused fluid retention and increased levels of natriuretic peptides suggesting increased cardiac load (Papers II & IV). While pioglitazone improved insulin sensitivity and lipids, insulin glargine resulted in improved β-cell function (Paper IV). Pioglitazone also caused an increase in eye protrusion in a subgroup of patients, probably by causing an increase in retrobulbar adipogenesis (Paper III). Taken together, these results can hopefully help clinicians in the choice of novel add-on treatment and in monitoring of untoward side effects. GITT seems to be a promising tool for assessing insulin secretion and action in clinical practice.
Department/s
Publishing year
2008
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2008:49
Full text
- Available as PDF - 752 kB
- Download statistics
Document type
Dissertation
Publisher
Department of Clinical Sciences, Lund University
Topic
- Endocrinology and Diabetes
Keywords
- Type 2 diabetes
- insulin secretion
- glucagon test
- insulin resistance
- insulin glargine
- insulin tolerance test
- thiazolidinediones
- natriuretic peptides
- adiponectin
- thyroid associated ophthalmopathy
- proinsulin
Status
Published
Research group
- Genomics, Diabetes and Endocrinology
Supervisor
- Leif Groop
- Anders Frid
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-86059-02-6
Defence date
9 May 2008
Defence time
09:00
Defence place
Stora Aulan, Medicinsk Forskningscentrum, Ingång 59, Universitetssjukhuset MAS, Malmö
Opponent
- Christian Berne (Professor)