Early Cellular Pathways of Mouse Natural Killer Cell Development.
Author
Summary, in English
Natural killer (NK) cells are large granular lymphocytes that are components of the innate immune system. These cells are key players in the defense against viral and other microbial infections and cancer and have an important function during pregnancy, autoimmunity and allergy. Furthermore, NK cells play important roles in hematopoietic stem cell (HSC) transplantation by providing the graft versus leukemia effect and preventing the development of graft versus host disease. Thus, understanding the developmental pathway(s) from multipotent HSCs to the NK cell lineage-restricted progenitors is of significant clinical value. However, despite extensive progress in the delineation of mature blood cell development, including the B- and T-cell lineages, the early stages of NK cell lineage commitment and development have been less well established and characterized. Here, I review the progress made thus far in dissecting the developmental stages, from HSCs in the bone marrow to the lineage-committed NK cells in mouse.
Department/s
Publishing year
2011
Language
English
Pages
329-336
Publication/Series
Journal of Innate Immunity
Volume
3
Issue
4
Full text
Links
Document type
Journal article review
Publisher
Karger
Topic
- Immunology in the medical area
Status
Published
Research group
- Lymphoid Development and Regulation
ISBN/ISSN/Other
- ISSN: 1662-811X