Validation of brief cognitive tests in mild cognitive impairment, Alzheimer's disease and dementia with Lewy bodies.
Användning och tolkning av enkla kognitiva tester vid mild kognitiv svikt, Alzheimers sjukdom och Lewy body demens
Author
Summary, in English
Background
It is estimated that 34 million people suffer from dementia, costing society US$422 billion each year. Alzheimer’s disease (AD) is the most common dementia and the global prevalence is predicted to increase to over 100 million people by the year 2050, with the greatest increase in developing countries. Therefore, inexpensive and efficient instruments are required for investigation and evaluation.
Aim
To evaluate the brief cognitive tests cube copying, clock drawing, the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT) in the early diagnosis, treatment evaluation and differential diagnosis of dementias.
Populations
I. 85 patients with AD.
II. 33 patients with dementia with Lewy bodies (DLB) and 66 with AD.
III. 75 patients with AD.
IV. 99 patients with mild cognitive impairment (MCI).
Findings
I. Cube copying was found useful for evaluating treatment with acetylcholinesterase inhibitors (AChEI) in patients with AD.
II. Easy and quick interpretations of the MMSE, clock drawing and cube copying differentiated patients with DLB from patients with AD.
III. AQT was twice as sensitive as the MMSE in detecting treatment response to AChEI in patients with AD.
IV. The MMSE, AQT and clock drawing were as accurate as cerebrospinal fluid biomarkers (tau, Aβ42 and P-tau) in predicting development of AD and dementia in mild cognitive impairment during an average of five years.
Conclusion
This thesis has improved the validity of brief cognitive tests and contributed with results that can be clinically relevant for evaluating treatment of AD, differentiating DLB from AD, and predicting development of AD and other dementias.
It is estimated that 34 million people suffer from dementia, costing society US$422 billion each year. Alzheimer’s disease (AD) is the most common dementia and the global prevalence is predicted to increase to over 100 million people by the year 2050, with the greatest increase in developing countries. Therefore, inexpensive and efficient instruments are required for investigation and evaluation.
Aim
To evaluate the brief cognitive tests cube copying, clock drawing, the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT) in the early diagnosis, treatment evaluation and differential diagnosis of dementias.
Populations
I. 85 patients with AD.
II. 33 patients with dementia with Lewy bodies (DLB) and 66 with AD.
III. 75 patients with AD.
IV. 99 patients with mild cognitive impairment (MCI).
Findings
I. Cube copying was found useful for evaluating treatment with acetylcholinesterase inhibitors (AChEI) in patients with AD.
II. Easy and quick interpretations of the MMSE, clock drawing and cube copying differentiated patients with DLB from patients with AD.
III. AQT was twice as sensitive as the MMSE in detecting treatment response to AChEI in patients with AD.
IV. The MMSE, AQT and clock drawing were as accurate as cerebrospinal fluid biomarkers (tau, Aβ42 and P-tau) in predicting development of AD and dementia in mild cognitive impairment during an average of five years.
Conclusion
This thesis has improved the validity of brief cognitive tests and contributed with results that can be clinically relevant for evaluating treatment of AD, differentiating DLB from AD, and predicting development of AD and other dementias.
Department/s
Publishing year
2011
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2011:64
Full text
Document type
Dissertation
Publisher
Clinical Memory Research Unit, Lund University
Topic
- Medical and Health Sciences
- Clinical Medicine
- Neurology
Keywords
- Cognitive tests
- neuropsychology
- Alzheimer’s disease
- dementia with Lewy bodies
- mild cognitive impairment
- treatment evaluation
- acetylcholinesterase inhibitors
- differential diagnosis
- longitudinal studies
- dementia
- cerebrospinal fluid
- forecasting
Status
Published
Research group
- Clinical Memory Research
Supervisor
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-86871-13-0
Defence date
18 June 2011
Defence time
09:00
Defence place
The Main Lecture Hall at the Clinical Research Centre (CRC), Entrance 72, Skåne University Hospital, Malmö, Sweden
Opponent
- Knut Engedal (MD)