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Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster

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Author

  • Stina Lundgren
  • Birgit Andersen
  • Jure Piskur
  • Doreen Dobritzsch

Summary, in English

beta-Alanine synthase catalyzes the last step in the reductive degradation pathway for uracil and thymine, which represents the main clearance route for the widely used anticancer drug 5-fluorouracil. Crystals of the recombinant enzyme from Drosophila melanogaster, which is closely related to the human enzyme, were obtained by the hanging-drop vapour-diffusion method. They diffracted to 3.3 angstrom at a synchrotron-radiation source, belong to space group C2 (unit-cell parameters a = 278.9, b = 95.0, c = 199.3 angstrom, beta = 125.8 degrees) and contain 8-10 molecules per asymmetric unit.

Publishing year

2007

Language

English

Pages

874-877

Publication/Series

Acta Crystallographica. Section F: Structural Biology and Crystallization Communications

Volume

63

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Biological Sciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 2053-230X