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Thymidine kinase diversity in bacteria

Author

  • Michael Sandrini
  • Anders Ranegaard Clausen
  • Birgitte Munch-Petersen
  • Jure Piskur

Summary, in English

Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.

Publishing year

2006

Language

English

Pages

1153-1158

Publication/Series

Nucleosides, Nucleotides & Nucleic Acids

Volume

25

Issue

9-11

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Biological Sciences

Keywords

  • pyrimidines
  • nucleosides
  • thymidine kinase
  • deoxyribonucleoside kinase
  • evolution
  • nucleic acids precursors

Status

Published

ISBN/ISSN/Other

  • ISSN: 1525-7770