Thymidine kinase diversity in bacteria
Author
Summary, in English
Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.
Department/s
Publishing year
2006
Language
English
Pages
1153-1158
Publication/Series
Nucleosides, Nucleotides & Nucleic Acids
Volume
25
Issue
9-11
Document type
Journal article
Publisher
Taylor & Francis
Topic
- Biological Sciences
Keywords
- pyrimidines
- nucleosides
- thymidine kinase
- deoxyribonucleoside kinase
- evolution
- nucleic acids precursors
Status
Published
ISBN/ISSN/Other
- ISSN: 1525-7770