The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

A multisubstrate deoxyribonucleoside kinase from plants.

På svenska

Author

  • Anders Ranegaard Clausen
  • Lenart Girandon
  • Wolfgang Knecht
  • Sabeen Survery
  • Erik Andreasson
  • Birgitte Munch-Petersen
  • Jure Piskur

Summary, in English

Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

Publishing year

2008

Language

English

Pages

489-490

Publication/Series

Nucleic acids symposium series

Issue

52

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Biological Sciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 0261-3166