The global distribution and evolution of deoxyribonucleoside kinases in bacteria
Author
Summary, in English
Deoxyribonucleoside kinases (dNKs) are important to DNA metabolism, especially in environments where nucleosides are freely available to be absorbed and used for the salvage pathway. Little has previously been known about the complement of dNKs in different bacterial genomes. However, it was believed that Gram-negative bacteria had a single dNK, while Gram-positive bacteria possessed several. An analysis of 992 fully sequenced bacterial genomes, including both Gram-positive and Gram-negative organisms, was conducted to investigate the phylogenetic relationship of all TK1-like and non-TK1-like dNKs. It was illustrated that both gene families evolved through a number of duplications and horizontal gene transfers, leading to the presence of multiple dNKs in different types of bacteria. The findings of this study provide a backbone for further studies into the evolution of the interplay between the de novo and salvage pathways in DNA synthesis with respect to environmental availability of deoxyribonucleosides and metabolic processes generating the provisions of different dNTPs. (C) 2011 Elsevier B.V. All rights reserved.
Department/s
Publishing year
2012
Language
English
Pages
117-120
Publication/Series
Gene
Volume
492
Issue
1
Document type
Journal article
Publisher
Elsevier
Topic
- Biological Sciences
Keywords
- Deoxyribonucleoside kinase
- Evolution
- Phylogeny
- Salvage pathway
- Gene
- duplication
- Horizontal transfer
Status
Published
ISBN/ISSN/Other
- ISSN: 1879-0038