Hedgehog, but not Odd skipped, induces segmental grooves in the Drosophila epidermis.
Author
Summary, in English
The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well understood. We report that although groove cells originate from a population of Odd skipped-expressing cells, this pair-rule transcription factor is not required for their specification. We further find that Hedgehog is sufficient to specify groove fate in cells of different origin as late as stage 10, suggesting that Hedgehog induces groove cell fate rather than maintaining a pre-established state. Wingless activity is continuously required in the posterior part of parasegments to antagonize segmental groove formation. Our data support an instructive role for the Wingless/Hedgehog organizer in cellular patterning.
Publishing year
2009
Language
English
Pages
3875-3880
Publication/Series
Development: For advances in developmental biology and stem cells
Volume
136
Issue
23
Full text
Links
Document type
Journal article
Publisher
The Company of Biologists Ltd
Topic
- Developmental Biology
Status
Published
Research group
- Invertebrate Developmental Biology, Udo Haecker's group
ISBN/ISSN/Other
- ISSN: 1477-9129