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Hedgehog, but not Odd skipped, induces segmental grooves in the Drosophila epidermis.

Author

Summary, in English

The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well understood. We report that although groove cells originate from a population of Odd skipped-expressing cells, this pair-rule transcription factor is not required for their specification. We further find that Hedgehog is sufficient to specify groove fate in cells of different origin as late as stage 10, suggesting that Hedgehog induces groove cell fate rather than maintaining a pre-established state. Wingless activity is continuously required in the posterior part of parasegments to antagonize segmental groove formation. Our data support an instructive role for the Wingless/Hedgehog organizer in cellular patterning.

Publishing year

2009

Language

English

Pages

3875-3880

Publication/Series

Development: For advances in developmental biology and stem cells

Volume

136

Issue

23

Document type

Journal article

Publisher

The Company of Biologists Ltd

Topic

  • Developmental Biology

Status

Published

Research group

  • Invertebrate Developmental Biology, Udo Haecker's group

ISBN/ISSN/Other

  • ISSN: 1477-9129