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Estimating the distribution of the G2 phase duration from flow cytometric histograms

Author

Summary, in English

A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S phase duration and the estimated means and standard deviations of the G2 phase duration are all in the same range.

Publishing year

2008

Language

English

Pages

1-17

Publication/Series

Mathematical Biosciences

Volume

211

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology

Keywords

  • Cell cycle progression
  • Branching process
  • G2 phase duration
  • Flow cytometry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0025-5564