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Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development

Author

  • Ulf Gurok
  • Kaya Bork
  • Ulrike Nuber
  • Ralf Sporle
  • Sabine Nohring
  • Rudiger Horstkorte

Summary, in English

Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation. NP15.6 is homologous to the bovine protein ESSS, a component of the mitochondrial complex 1. The homologous human NDUFB11 gene is localized to Xp11.3-Xp11.23, a region associated with neurogenetic disorders. The down-regulation of NP15.6 correlates with neurite outgrowth of PC12 cells induced by nerve growth factor. Furthermore, we analyzed the expression of Ndufb11 in the embryonic and adult mouse.

Publishing year

2007

Language

English

Pages

370-374

Publication/Series

Gene Expression Patterns

Volume

7

Issue

3

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1567-133X