The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Screening för celiaki kan vara motiverad i högriskgrupper

Screening for celiac disease can be justified in high-risk groups

På svenska

Author

Summary, in English

Coeliac disease is widespread and occurs in 0.5-1 per cent of the population. Most sufferers show atypical symptoms and might well remain undiagnosed. Endomysial or human transglutaminase autoantibody levels of type IgA can be recommended as screening instruments combined with s-IgA for exclusion of such deficiency. In contrast, there is a high frequency of false-positive IgA gliadin antibody test results, especially where coeliac disease is common, as in chronic liver disease, diabetes, thyroid disease and conditions with chromosomal aberrations (Down syndrome and Turner syndrome). Despite this, gliadin antibodies of type IgA are still the best marker for coeliac disease in children under two years of age. While mass screening is not to be recommended, case finding is worthwhile in well defined risk groups, i.e. in cohorts with autoimmune disease or chromosomal aberrations or in relatives to anyone with coeliac disease. A positive biopsy is still the gold standard for diagnosis.

Department/s

Publishing year

2004

Language

Swedish

Pages

6-3918

Publication/Series

Läkartidningen

Volume

101

Issue

48

Document type

Journal article

Publisher

Swedish Medical Association

Topic

  • Gastroenterology and Hepatology

Keywords

  • Humans
  • Gliadin: immunology
  • English Abstract
  • Child
  • Celiac Disease: immunology
  • Celiac Disease: genetics
  • Celiac Disease: diagnosis
  • Celiac Disease: complications
  • Biological Markers: blood
  • Autoimmune Diseases: diagnosis
  • Adult
  • Autoimmune Diseases: complications
  • Transglutaminases: immunology
  • Risk Factors
  • Myosins: immunology
  • Immunoglobulin A: blood
  • Mass Screening

Status

Published

Research group

  • Gastroenterology
  • Chronic Inflammatory and Degenerative Diseases Research Unit

ISBN/ISSN/Other

  • ISSN: 0023-7205