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An improved probing controller for substrate feeding in fed-batch culteres of E. coli: simulations and experiments

Author

Summary, in English

A strategy for feedback control of the glucose feed rate in cultivations of E.coli is discussed. By making probing pulses in the feedrate it is possible to detect and avoid undesirable by-productformation using a standard dissolved oxygen sensor. The feasibility of an improved and simplified probing algorithm is demonstrated by simulations as well as laboratory-scale experiments.

Publishing year

2002

Language

English

Pages

213-218

Publication/Series

Computer Applications in Biotechnology 2001

Document type

Conference paper

Publisher

Elsevier

Topic

  • Control Engineering

Keywords

  • Fermentation process
  • probing
  • extremum control
  • process control

Conference name

8th IFAC International Conference on Computer Applications in Biotechnology (CAB8)

Conference date

2001-06-24 - 2001-06-27

Conference place

Quebeq City, Canada

Status

Published

ISBN/ISSN/Other

  • ISBN: 0080436811