The Epidemiology of Childhood Celiac Disease: A Social Epidemiological Perspective on Perinatal Factors
Author
Summary, in English
Celiac disease is a chronic gastrointestinal disease affecting approximately 1% of the population. It is precipitated in genetically predisposed individuals by ingestion of food containing gluten or similar proteins
that are present in wheat, rye and barley. The disease might present with symtoms such as malnutrition, diarrhea or abdominal bloating, but a large proportion of those afflicted by the disease are asymptomatic. We
set out to study risk factors for celiac disease in children using a social epidemiological approach; besides the individual risk factors we also consider the importance of societal structures in conditioning disease risk. We investigated all children born in Sweden between 1987 and 1993 by linking several nationwide registers. We apply epidemiological methods such as multilevel analyses and sibling designs in order to approach causality.
We observed that children exposed to adverse perinatal circumstances such as being born small for gestational age, born in families with lower socioeconomic position or having a congenital anomaly had a higher risk of
CD. These associations were stronger in boys. We also observed that maternal CD seems not to be the cause of the previously reported increased risk of CD in girls. Furthermore, we observed that maternal length of stay in
Sweden seems to affect the risk of CD in second-generation immigrant children. Future studies are needed to investigate risk factors for celiac disease in children; focusing especially on the mechanisms behind the
observed associations.
that are present in wheat, rye and barley. The disease might present with symtoms such as malnutrition, diarrhea or abdominal bloating, but a large proportion of those afflicted by the disease are asymptomatic. We
set out to study risk factors for celiac disease in children using a social epidemiological approach; besides the individual risk factors we also consider the importance of societal structures in conditioning disease risk. We investigated all children born in Sweden between 1987 and 1993 by linking several nationwide registers. We apply epidemiological methods such as multilevel analyses and sibling designs in order to approach causality.
We observed that children exposed to adverse perinatal circumstances such as being born small for gestational age, born in families with lower socioeconomic position or having a congenital anomaly had a higher risk of
CD. These associations were stronger in boys. We also observed that maternal CD seems not to be the cause of the previously reported increased risk of CD in girls. Furthermore, we observed that maternal length of stay in
Sweden seems to affect the risk of CD in second-generation immigrant children. Future studies are needed to investigate risk factors for celiac disease in children; focusing especially on the mechanisms behind the
observed associations.
Publishing year
2012
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2012:98
Full text
Document type
Dissertation
Publisher
Department of Clinical Sciences, Lund University
Topic
- Environmental Health and Occupational Health
Keywords
- Celiac Disease
- Children
- Risk Factors
- Sibling design
- Social Epidemiology
Status
Published
Research group
- Social Epidemiology
Supervisor
- Juan Merlo
- Daniel Agardh
- Kristian Lynch
- Henrik Ohlsson
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-87189-61-6
Defence date
6 December 2012
Defence time
09:00
Defence place
The auditorium of the clinic of internal medicine, Inga Marie Nilssons gata 46, Skåne University Hospital, Malmö
Opponent
- Jonas Ludvigsson (Associate Professor)