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The human antibody repertoire to infectious agents: implications for disease pathogenesis

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Author

Summary, in English

Antibodies are critical entities used for the protection of an individual organism against infection and disease. Through a complex series of events genes rearrange to encode repertoires of molecules, which are tested for their ability to identify foreign molecules. In this report, we discuss factors defined by the individual as well as by infectious organisms that shape the antibody repertoire. A more thorough understanding of the interplay between these factors will eventually allow us to elucidate the underlying mechanisms of disease susceptibility following infection, and to design potent vaccines and other immunomodulating reagents.

Publishing year

2003

Language

English

Pages

1-11

Publication/Series

Molecular Immunology

Volume

40

Issue

1

Document type

Journal article review

Publisher

Pergamon Press Ltd.

Topic

  • Immunology in the medical area

Status

Published

ISBN/ISSN/Other

  • ISSN: 1872-9142