Lung function in relation to 2-thiothiazolidine-4-carboxylic Acid and genetic effect modification among rubber workers in sweden.

Summary, in English

OBJECTIVE:: What is the risk of impaired lung function in contemporary Swedish rubber workers and are there modifying effects of genetic variants? METHODS:: Included in the study were 159 rubber exposed and 118 not-rubber exposed workers. Lung function was analyzed as forced vital capacity percent of predicted and forced expiratory volume in 1 second percent of predicted. Levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) was assessed with liquid chromatography tandem mass spectrometry. Polymorphisms in glutathione-related genes were analyzed by Taqman-based allelic discrimination and ordinary polymerase chain reaction. RESULTS:: There was an association between increasing levels of 2-thiothiazolidine-4-carboxylic acid and impaired lung function among exposed workers. The association was modified by glutathione S-transferase alpha 1 (GSTA1)-52 and GSTP1-114. GSTM1 had an influence on lung function among unexposed workers. CONCLUSIONS:: There may be a risk of impaired lung function in contemporary rubber workers. Gene-modifying effects may be considered in risk assessments.

• Author: Lena S Jönsson; Margareta Littorin; Anna Axmon; Bo A Jönsson; Karin Broberg Palmgren
• Department/s: Division of Occupational and Environmental Medicine, Lund University
• Publishing year: 2008
• Language: English
• Pages: 1006-1012
• Publication/Series: Journal of Occupational and Environmental Medicine
• Volume: 50
• Issue: 9
• Full text: - 151 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/18784548?dopt=Abstract; http://dx.doi.org/10.1097/JOM.0b013e3181715126
• Document type: Journal article
• Publisher: Lippincott Williams & Wilkins
• Topic: Environmental Health and Occupational Health
• Status: Published
• ISBN/ISSN/Other: ISSN: 1536-5948