The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

På svenska

Author

  • X. Li
  • A. Pontén
  • K. Aase
  • L. Karlsson
  • A. Abramsson
  • M. Uutela
  • G. Bäckström
  • M. Hellström
  • Hans Ehrencrona
  • H. Li
  • P. Soriano
  • C. Betsholtz
  • C. H. Heldin
  • K. Alitalo
  • A. Ostman
  • U. Eriksson
Show all

Summary, in English

Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

Publishing year

2000

Language

English

Pages

302-309

Publication/Series

Nature Cell Biology

Volume

2

Issue

5

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cell and Molecular Biology

Keywords

  • Platelet-Derived Growth Factor
  • Myocardium
  • Molecular Sequence Data
  • Mice
  • Mesoderm
  • Lymphokines
  • Ligands
  • Kidney
  • Insects
  • In Situ Hybridization
  • Humans
  • Developmental
  • Gene Expression Regulation
  • Gene Expression
  • Epithelial Cells
  • Endopeptidases
  • Animals
  • COS Cells
  • Protein Structure
  • Tertiary
  • RNA
  • Messenger
  • Rabbits
  • Receptor
  • Platelet-Derived Growth Factor alpha
  • Sequence Homology
  • Amino Acid
  • Transgenes

Status

Published

ISBN/ISSN/Other

  • ISSN: 1465-7392