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Ductus venosus blood flow velocity waveform in diabetic pregnancies

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Author

Summary, in English

Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of the DV (DV-PI) was analyzed retrospectively in 142 diabetic patients and compared to previously published DV-PI reference values from a non-diabetic low-risk population. DV values were then correlated with maternal glycosylated hemoglobin (HbA1c). Results DV-PI was significantly higher in pregnancies complicated by either pre-existing insulin-dependent (DM) or gestational diabetes when compared with normal reference values. Increased DV-PI values were still evident in both diabetic groups when neonates that were small-for-gestational age and neonates with pathological umbilical blood flow pattern were excluded from the analysis. In DM pregnancies a statistically significant correlation was found between DV-PI and maternal HbA1c. Conclusion Diabetic pregnancies exhibit increased DV-PI values when compared to a normal low-risk pregnant population, possibly indicating a fetal cardiac effect. Copyright (C) 2010 ISUOG. Published by John Wiley & Sons, Ltd.

Publishing year

2010

Language

English

Pages

344-349

Publication/Series

Ultrasound in Obstetrics & Gynecology

Volume

36

Issue

3

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • pulsatility index
  • large-for-gestational age
  • diabetes
  • ductus venosus

Status

Published

Research group

  • Urogynaecology and Reproductive Pharmacology
  • Tornblad Institute

ISBN/ISSN/Other

  • ISSN: 1469-0705