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Pericytes: gatekeepers in tumour cell metastasis?

Author

  • H Gerhardt
  • Henrik Semb

Summary, in English

Tumour cells use two major routes to spread during metastasis, e.g. lymph vessels and blood vessels within or surrounding the primary tumour. The growth rate of the primary tumour often correlates with the quantity of new blood vessels that form within the tumour. However, qualitative abnormalities of the tumour vasculature profoundly affect the perfusion of the primary tumour and the escape of tumour cells into the circulation. In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis.

Department/s

Publishing year

2008

Language

English

Pages

135-144

Publication/Series

Journal of Molecular Medicine

Volume

86

Issue

2

Document type

Journal article review

Publisher

Springer

Topic

  • Cell and Molecular Biology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1432-1440