Pericytes: gatekeepers in tumour cell metastasis?
Author
Summary, in English
Tumour cells use two major routes to spread during metastasis, e.g. lymph vessels and blood vessels within or surrounding the primary tumour. The growth rate of the primary tumour often correlates with the quantity of new blood vessels that form within the tumour. However, qualitative abnormalities of the tumour vasculature profoundly affect the perfusion of the primary tumour and the escape of tumour cells into the circulation. In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis.
Department/s
Publishing year
2008
Language
English
Pages
135-144
Publication/Series
Journal of Molecular Medicine
Volume
86
Issue
2
Document type
Journal article review
Publisher
Springer
Topic
- Cell and Molecular Biology
Status
Published
ISBN/ISSN/Other
- ISSN: 1432-1440