Compact archaeal variant of heme A synthase
Author
Summary, in English
The N- and C-terminal halves of the heme A synthase polypeptide of Bacillus subtilis, and many other organisms, are homologous. This indicates that these enzyme proteins originate from a tandem duplication and fusion event of a gene encoding a protein half as large. The ape1694 gene of the hyperthermophilic archaeon Aeropyrum pernix encodes a protein that is similar to the hypothetical small primordial protein. We demonstrate that this A. pernix protein is a heat-stable membrane bound heme A synthase designated cCtaA. The case of cCtaA is unusual in evolution in that the primordial-like protein has not become extinct and apparently carries out the same function as the twice as large more diversified heme A synthase protein variant found in most cytochrome a-containing organisms.
Department/s
Publishing year
2006
Language
English
Pages
5351-5356
Publication/Series
FEBS Letters
Volume
580
Issue
22
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Biological Sciences
Keywords
- Aeropyrum
- protein evolution
- ape1694
- heme A synthesis
- CtaA
- cCtaA
- pernix
Status
Published
ISBN/ISSN/Other
- ISSN: 1873-3468