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Influence of alpha-ketoglutarate on bone mineral density of the femur in piglets

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Author

Summary, in English

The aim of this study was to determine the influence of daily oral administration of alpha-ketoglutarate (AKG) on bone mineral density of the femur and concentration of 17-beta-oestradiol in blood plasma during 70 d of postnatal life in piglets. All the animals were kept under standard rearing conditions. AKG was administered orally from the 1(st) d of life, while the control piglets were treated in the same way and time with physiological saline. The experimental and control groups were assigned to 6 age subgroups: 3, 14, 21, 35, 56 and 70 d of life. The animals from both groups were euthanised, then bone samples were collected and frozen at -25 degrees C until further analyses. Using dual-energy x-ray absorptiometry (DEXA method) bone mineral density of the femora was estimated. Additionally, 17-beta-oestradiol concentration in blood plasma was assayed using RIA-test. The obtained results indicate positive influence of enteral AKG administration on bone mineral density of the femur in piglets. Moreover, AKG increased the level of 17-beta-oestradiol in blood plasma in post-weaned piglets.

Department/s

Publishing year

2005

Language

English

Pages

343-348

Publication/Series

Bulletin of the Veterinary Institute in Puławy

Volume

49

Issue

3

Document type

Journal article

Publisher

National Veterinary Research Institute

Topic

  • Zoology

Keywords

  • 17-beta-oestradiol
  • bone mineral density
  • femur
  • piglets
  • alpha-ketoglutarate

Status

Published

ISBN/ISSN/Other

  • ISSN: 0042-4870