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State-of-the-art MS technology applications in lung disease.

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Author

  • Ákos Végvári
  • Balázs Döme

Summary, in English

Two frontline MS technologies, which have recently gained much attention, are discussed within the scope of this review. Besides a brief summary on the contemporary state of lung cancer and chronic obstructive pulmonary disease, the principles of multiple reaction monitoring and matrix assisted laser desorption ionization (MALDI) MS imaging are presented. A comprehensive overview of quantitative mass spectrometry applications is provided, covering multiple reaction monitoring assay developments for analysis of proteins (biomarkers) and low-molecular-weight compounds (drugs) with a special focus on the disease areas of lung cancer and chronic obstructive pulmonary disease. The MALDI-MS imaging applications are discussed similarly, providing references to studies conducted on lung tissues in order to localize drug compounds and protein biomarkers.

Publishing year

2011

Language

English

Pages

2665-2677

Publication/Series

Bioanalysis

Volume

3

Issue

23

Document type

Journal article review

Publisher

Future Science

Topic

  • Pharmacology and Toxicology

Keywords

  • Lung cancer
  • Non-small cell lung cancer
  • Chronic obstructive pulmonary disease
  • Mass spectrometry
  • Multiple reaction monitoring
  • MALDI mass spectrometry imaging
  • Personalized medicine

Status

Published

ISBN/ISSN/Other

  • ISSN: 1757-6180