C-terminal flanking peptide of neuropeptide Y in DRG following nerve compression
Author
Summary, in English
The C-terminal flanking peptide of neuropeptide Y (CPON) was studied in dorsal root ganglia (DRG) by immunocytochemistry after different recovery periods (3, 6,14 and 28 days) following tourniquet compression of the rat hindlimb (sciatic nerve; 150 or 300 mmHg; 2 h). Compression induced a transient increase in the number of CPON-positive DRG-neurons (the contralateral uninjured side was devoid of CPON-positive cells). The compression-induced increase in CPON was less than that observed in separate rats subjected to sciatic nerve transection. The results show that compression induces regenerative changes in peripheral neurons and that such an injury of the nerve trunk is not limited to the site of the compression but results in the activation of the entire neuron.
Publishing year
2001
Language
English
Pages
3193-3196
Publication/Series
NeuroReport
Volume
12
Issue
15
Document type
Journal article
Publisher
Lippincott Williams & Wilkins
Topic
- Neurosciences
Keywords
- C-terminal flanking peptide of neuropeptide Y (CPON)
- Nerve compression
- Nerve injury
- Neuron
- Neuropeptide Y
- NPY
- Tourniquet
Status
Published
Research group
- Hand Surgery, Malmö
ISBN/ISSN/Other
- ISSN: 1473-558X