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Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

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Author

  • S Mathas
  • M Janz
  • F Hummel
  • M Hummel
  • B Wollert-Wulf
  • S Lusatis
  • I Anagnostopoulos
  • A Lietz
  • Mikael Sigvardsson
  • F Jundt
  • K Johrens
  • K Bommert
  • H Stein
  • B Dorken
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Summary, in English

B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell-specific transcription factor program was disrupted by overexpression of the helix-loop-helix proteins ABF-1 and Id2. Both factors antagonized the function of the B cell-determining transcription factor E2A. As a result, expression of genes specific to B cells was lost and expression of genes not normally associated with the B lineage was upregulated. These data demonstrate the plasticity of mature human lymphoid cells and offer an explanation for the unique classical Hodgkin lymphoma phenotype.

Department/s

Publishing year

2006

Language

English

Pages

207-215

Publication/Series

Nature Immunology

Volume

7

Issue

2

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cell and Molecular Biology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1529-2908