Bioreactor control using a probing feeding strategy and mid-ranging control
Author
Summary, in English
The paper presents a fed-batch fermentation technique for bioreactors operating close to their maximum oxygen transfer capacity. The method combines the advantages of the probing feeding strategy and the temperature limited fed-batch technique. When the maximum oxygen transfer capacity of the reactor is reached, the temperature is decreased to lower the oxygen demand. To achieve a good control of the dissolved oxygen a mid-ranging controller manipulating the stirrer speed and the temperature is used. The feeding strategy is analysed and it is also illustrated by simulations and an experiment. (c) 2006 Elsevier Ltd. All rights reserved.
Department/s
Publishing year
2007
Language
English
Pages
135-147
Publication/Series
Control Engineering Practice
Volume
15
Issue
2
Links
Document type
Journal article
Publisher
Elsevier
Topic
- Control Engineering
Keywords
- temperature
- mid-ranging
- control
- dissolved oxygen
- probing
- fermentation processes
- feeding strategy
Status
Published
ISBN/ISSN/Other
- ISSN: 0967-0661