Identification of a NK/T cell restricted progenitor in adult bone marrow contributing to bone marrow and thymic-dependent NK cells.

Summary, in English

Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1(-)DX5(-) NK-cell progenitors failed to commit to the B and myeloid lineages, they sustained a combined NK- and T-cell potential in vivo and in vitro at the single-cell level. Whereas T-cell development from NK/T progenitors is Notch-dependent, their contribution to thymic and BM NK cells remains Notch-independent. These findings demonstrate the existence of bipotent NK-/T-cell progenitors in adult BM. (Blood. 2010; 116(2): 183-192)

• Author: Hojjatollah NozadCharoudeh; Yan-Juan Tang; Min Cheng; Corrado Cilio; Sten Eirik W Jacobsen; Ewa Sitnicka Quinn
• Department/s: Lymphoid Development and Regulation; Stem Cell Center; EXODIAB: Excellence of Diabetes Research in Sweden; Diabetes - Immunovirology; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
• Publishing year: 2010
• Language: English
• Pages: 183-192
• Publication/Series: Blood
• Volume: 116
• Issue: 2
• Links: http://dx.doi.org/10.1182/blood-2009-10-247130
• Document type: Journal article
• Publisher: American Society of Hematology
• Topic: Hematology
• Status: Published
• Research group: Lymphoid Development and Regulation; Diabetes - Immunovirology
• ISBN/ISSN/Other: ISSN: 1528-0020