Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.

Summary, in English

The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.

• Author: Stefan Acosta; Nishtman Dizeyi; R Feinstein; Stefan Pierzynowski; Per-Anders Abrahamsson
• Department/s: Department of Clinical Sciences, Malmö; Urological research, Malmö; Functional zoology
• Publishing year: 2004
• Language: English
• Pages: 227-231
• Publication/Series: Prostate Cancer and Prostatic Diseases
• Volume: 7
• Issue: 3
• Full text: - 134 kB; Download statistics
• Links: http://dx.doi.org/10.1038/sj.pcan.4500744
• Document type: Journal article
• Publisher: Nature Publishing Group
• Topic: Obstetrics, Gynecology and Reproductive Medicine
• Status: Published
• Research group: Urological research, Malmö
• ISBN/ISSN/Other: ISSN: 1476-5608