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New directions of miniaturization within the biomarker research area

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Author

Summary, in English

An overview of the current trends within protein expression profiling is given where multidimensional separation of both gel and liquid phase techniques linked to mass spectrometry is viewed as a major route in the global proteome mapping. A clear trend in these biochemical developments is the effort to sequence and identify low-abundant protein expressions where assay miniaturization and integrated sample processing play a central role. Two areas of miniaturization within the proteomics field are addressed: (i) sample cleanup and enrichment, and (ii) silicon microstructure developments for protein chip microarrays.

Publishing year

2004

Language

English

Pages

3479-3491

Publication/Series

Electrophoresis

Volume

25

Issue

21-22

Document type

Journal article review

Publisher

John Wiley & Sons Inc.

Topic

  • Medical Engineering
  • Analytical Chemistry

Keywords

  • Review
  • Biomarker
  • Miniaturization

Status

Published

ISBN/ISSN/Other

  • ISSN: 0173-0835