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Modelling of nonlinear effects and the response of ultrasound contrast micro bubbles: simulation and experiment

På svenska

Author

  • A Kvikliene
  • R Jurkonis
  • M Ressner
  • L Hoff
  • Tomas Jansson
  • B Janerot-Sjoberg
  • A Lukosevicius
  • P Ask

Summary, in English

The propagation of diagnostic ultrasonic imaging pulses in tissue and their interaction with contrast micro bubbles is a very complex physical process, which we assumed to be separable into three stages: pulse propagation in tissue, the interaction of the pulse with the contrast bubble, and the propagation of the scattered echo. The model driven approach is used to gain better knowledge of the complex processes involved. A simplified way of field simulation is chosen due to the complexity of the task and the necessity to estimate comparative contributions of each component of the process. Simulations are targeted at myocardial perfusion estimation. A modified method for spatial superposition of attenuated waves enables simulations of low intensity pulse pressure fields from weakly focused transducers in a nonlinear, attenuating, and liquid-like biological medium. These assumptions enable the use of quasi-linear calculations of the acoustic field. The simulations of acoustic bubble response are carried out with the Rayleigh-Plesset equation with the addition of radiation damping. Theoretical simulations with synthesised and experimentally sampled pulses show that the interaction of the excitation pulses with the contrast bubbles is the main cause of nonlinear scattering, and a 2-3 dB increase of second harmonic amplitude depends on nonlinear distortions of the incident pulse. (C) 2004 Elsevier B.V. All rights reserved.

Publishing year

2004

Language

English

Pages

301-307

Publication/Series

Proceedings of Ultrasonics International 2003 (Ultrasonics)

Volume

42

Issue

1-9

Document type

Conference paper

Publisher

Elsevier

Topic

  • Medical Engineering

Keywords

  • contrast agents
  • simulation
  • nonlinear
  • ultrasound

Conference name

Ultrasonics International 2003

Conference date

2003-06-30 - 2003-07-03

Status

Published

ISBN/ISSN/Other

  • ISSN: 0041-624X