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Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

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Author

  • Dalemari Crowther-Swanepoel
  • Peter Broderick
  • Maria Chiara Di Bernardo
  • Sara E. Dobbins
  • Maria Torres
  • Mahmoud Mansouri
  • Clara Ruiz-Ponte
  • Anna Enjuanes
  • Richard Rosenquist
  • Angel Carracedo
  • Jesper Jurlander
  • Elias Campo
  • Gunnar Juliusson
  • Emilio Montserrat
  • Karin E. Smedby
  • Martin J. S. Dyer
  • Estella Matutes
  • Claire Dearden
  • Nicola J. Sunter
  • Andrew G. Hall
  • Tryfonia Mainou-Fowler
  • Graham H. Jackson
  • Geoffrey Summerfield
  • Robert J. Harris
  • Andrew R. Pettitt
  • David J. Allsup
  • James R. Bailey
  • Guy Pratt
  • Chris Pepper
  • Chris Fegan
  • Anton Parker
  • David Oscier
  • James M. Allan
  • Daniel Catovsky
  • Richard S. Houlston
Show all

Summary, in English

To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.

Publishing year

2010

Language

English

Pages

59-132

Publication/Series

Nature Genetics

Volume

42

Issue

2

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Hematology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1546-1718