Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor
Author
Summary, in English
The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1.
Department/s
Publishing year
2001
Language
English
Pages
2215-2219
Publication/Series
NeuroReport
Volume
12
Issue
10
Document type
Journal article
Publisher
Lippincott Williams & Wilkins
Topic
- Neurosciences
Keywords
- Dorsal root ganglion
- Formalin test
- Inflammation
- Mechanical von Frey
- Neuropeptides
- PACAP
- Pain measurements
- Sciatic nerve injury
- Sensory thresholds
- Thermal laser
Status
Published
Research group
- Neural Interfaces
- Neurophysiology
ISBN/ISSN/Other
- ISSN: 1473-558X