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Regional cerebral blood flow and EEG in clinically diagnosed dementia with Lewy bodies and Alzheimer's disease.

Author

Summary, in English

This study was undertaken in order to compare regional cerebral blood now (rCBF) and EEG findings of patients with clinically diagnosed dementia with Lewy bodies (clinDLB) and Alzheimer’s disease (clinAD). Furthermore, within the clinDLB group to compare cases with and without neuropathologically verified Lewy bodies (LBs). When we studied 200 dementia cases in a prospective longitudinal dementia study, 48 had clinDLB and 45 clinAD in retrospective analyses. EEG information was analysed in 34 clinDLB and 28 clinAD patients and cerebral blood flow, measured with the Xe 133 inhalation method, in 26 clinDLB and 25 clinAD. There were no differences in EEG between the clinDLB and clinAD groups or between the cases with and without LBs. The rCBF patterns in the clinDLB and clinAD groups showed similar reductions in the temporoparietal areas. The rCBF in cases with LBs showed heterogeneous pathology. The imaging results in clinDLB and clinAD were strikingly similar. The EEG and rCBF could not differentiate between cases with or without LB. The study illustrates the lack of specific changes of EEG and rCBF in cases with LB pathology.

Publishing year

2003

Language

English

Pages

231-245

Publication/Series

Archives of Gerontology and Geriatrics

Volume

36

Issue

3

Document type

Journal article

Publisher

Elsevier

Topic

  • Geriatrics

Keywords

  • Dementia with Lewy bodies
  • Alzheimer's disease
  • EEG
  • Regional cerebral blood flow
  • Lewy bodies

Status

Published

Research group

  • Clinical Memory Research

ISBN/ISSN/Other

  • ISSN: 1872-6976