Conjugated linoleic acid increased C-reactive protein in human subjects
Author
Summary, in English
We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.
Publishing year
2005
Language
English
Pages
791-795
Publication/Series
British Journal of Nutrition
Volume
94
Issue
5
Document type
Journal article
Publisher
Cambridge University Press
Topic
- Nutrition and Dietetics
Keywords
- tumour necrosis
- conjugated linoleic acid
- C-reactive protein
- inflammation
- factor-alpha
Status
Published
Research group
- Cardiovascular Research - Immunity and Atherosclerosis
ISBN/ISSN/Other
- ISSN: 1475-2662