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Adaptive immune responses in atherosclerosis - or how to prolong the use of your yellow socks

Author

  • Daniel Kolbus

Summary, in English

Abstract



Atherosclerosis is a multifactorial disease, but an unbalanced immune system plays a critical role in the disease development. A common theory states that a continuous stress to the vascular vessel wall initiates a repair process that however is insufficient to completely heal the tissue. This imbalance is associated with accumulation of cholesterol, which is an essential component of cellular membranes, and inflammatory cells at the injury site. Since cholesterol particles are not normally accumulating extra-cellularly, they are affected by the inflammatory environment, which modifies the particle structure. Since this can be potentially dangerous an inflammatory response is initiated in order to remove the modified particles. However, the continuous stress leads to an imbalanced immune response, which aggravate the inflammation and leads to a larger wound. In this thesis I present two methods on how to balance the immune response in order to stabilize the wound and thereby reduce the risk of rupture. I also elucidate the role of CD8+ T lymphocytes in the development of atherosclerotic lesions and test the association between CD8+ T lymphocytes in blood and cardiovascular disease.

Publishing year

2011

Language

English

Publication/Series

Lund University Faculty of Medicine Doctoral Dissertation Series

Volume

2011:19

Document type

Dissertation

Publisher

Lund University

Topic

  • Cardiac and Cardiovascular Systems
  • Medical and Health Sciences
  • Clinical Medicine

Keywords

  • cationized BSA
  • Atherosclerosis
  • alum
  • CD8+ T cell
  • intima-media thickness

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis

Supervisor

ISBN/ISSN/Other

  • ISSN: 1652-8220
  • ISBN: 978-91-86671-68-6

Defence date

17 March 2011

Defence time

13:00

Defence place

The small Aula, Medical Research Center (MFC), entrance 59, SUS, Malmö

Opponent

  • Giuseppina Caligiuri