The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Physical Modeling of Protein Folding

Author

  • Stefan Wallin

Summary, in English

Sequence-based models for protein folding are developed and tested on peptides with both alpha- and beta-structure, and on small three-helix-bundle proteins. The interaction potentials of the models are minimalistic and based mainly on hydrogen bonding and effective hydrophobicity forces. By contrast, the geometric representation of the protein chain is detailed. We explore the thermodynamic behaviors of these models by using efficient Monte Carlo methods, and focus on obtaining a realistic physical description of the folding process. In particular, we investigate dynamical aspects of folding, such as `two-state' behavior and secondary structure formation. In addition, the thesis includes a study on similarity measures for protein structures.

Publishing year

2003

Language

English

Document type

Dissertation

Publisher

Department of Theoretical Physics, Lund University

Topic

  • Biophysics

Keywords

  • relativity
  • quantum mechanics
  • classical mechanics
  • three-helix bundle
  • similarity measure
  • Mathematical and general theoretical physics
  • protein dynamics
  • protein folding
  • two-state
  • Matematisk och allmän teoretisk fysik
  • thermodynamics
  • statistical physics
  • gravitation
  • klassisk mekanik
  • kvantmekanik
  • relativitet
  • statistisk fysik
  • termodynamik
  • Fysicumarkivet A:2003:Wallin

Status

Published

Supervisor

  • [unknown] [unknown]

ISBN/ISSN/Other

  • ISBN: 91-628-5671-5

Defence date

4 June 2003

Defence time

10:15

Defence place

Lecture Hall F, Dept. of Theoretical Physics

Opponent

  • Cecilia Clementi