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An Mhc class I allele associated to the expression of T-dependent immune response in the house sparrow

Author

Summary, in English

The major histocompatibility complex (Mhc) encodes for highly variable molecules, responsible for foreign antigen recognition and subsequent activation of immune responses in hosts. Mhc polymorphism should hence be related to pathogen resistance and immune activity, with individuals that carry either a higher diversity of Mhc alleles or one specific Mhc allele exhibiting a stronger immune response to a given antigen. Links between Mhc alleles and immune activity have never been explored in natural populations of vertebrates. To fill this gap, we challenged house sparrows (Passer domesticus) with two T-dependent antigens (phytohemagglutinin and sheep red blood cells) and examined both primary and secondary immune responses in relation to their Mhc class I genotypes. The total number of Mhc alleles had no influence on either primary or secondary response to the two antigens. One particular Mhc allele, however, was associated with an increased response to both antigens. Our results point toward a contribution of the Mhc, or of other genes in linkage disequilibrium with the Mhc, in the regulation of immune responses in a wild animal species.

Publishing year

2005

Language

English

Pages

782-789

Publication/Series

Immunogenetics

Volume

57

Issue

10

Document type

Journal article

Publisher

Springer

Topic

  • Biological Sciences

Status

Published

Research group

  • Molecular Ecology and Evolution Lab

ISBN/ISSN/Other

  • ISSN: 1432-1211