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Presence of a novel form of phosphatidylinositol 4-kinase in rat liver

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Author

  • Henric Olsson
  • Wilma Martinez Arias
  • Bjørn K Drøbak
  • Bengt Jergil

Summary, in English

Rat liver microsomes contain two distinct forms of PtdIns 4-kinase which were resolved by heparin-Sepharose chromatography. One enzyme was identified as the type II PtdIns kinase previously isolated from exocytotic vesicles. The other enzyme, however, was a novel PtdIns 4-kinase isoform with properties differing from any other PtdIns kinase so far characterized. Both kinases were recognized by a monoclonal antibody specific for type II PtdIns 4-kinase, but the novel enzyme was considerably less sensitive to inhibition by adenosine and Ca2+ than type II enzymes, and in addition was specifically inhibited by submillimolar concentrations of dithioerythritol. The presence of a novel PtdIns 4-kinase isoform in rat liver raises the question of whether this enzyme is unique for this organ or whether it has a more widespread distribution but so far has avoided detection.

Publishing year

1995

Language

English

Pages

282-286

Publication/Series

FEBS Letters

Volume

361

Issue

2-3

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Biological Sciences

Keywords

  • Signal transduction
  • Phosphoinositide
  • Phosphatidyl inositol 4-kinase
  • Rat liver

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-3468