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From the bone marrow to the thymus: the road map of early stages of T-cell development.

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Author

Summary, in English

The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the HSCs in the bone marrow to the lineage committed T cells inside the thymus.

Publishing year

2009

Language

English

Pages

487-530

Publication/Series

Critical Reviews in Immunology

Volume

29

Issue

6

Document type

Journal article review

Publisher

Begell House

Topic

  • Cell and Molecular Biology

Keywords

  • T-Lymphocytes: immunology
  • Thymus Gland: cytology
  • Thymus Gland: immunology
  • Bone Marrow: immunology
  • T-Lymphocytes: cytology

Status

Published

Research group

  • Lymphoid Development and Regulation

ISBN/ISSN/Other

  • ISSN: 1040-8401