Abdominal Aortic Aneurysm – Different Aspects on Screening
Author
Summary, in English
Abstract
Abdominal aortic aneurysm (AAA) is a hideous life threatening disease that most often is asymptomatic until it ruptures. Ruptured
abdominal aortic aneurysm (rAAA) is a painful and serious predicament with a mortality of 80-90%. Half of the patients die before
arriving to hospital, leaving family members in sorrow and shock. In Sweden about 700-1000 patients die each year due to rAAA,
corresponding to 1.5% of all deaths in men.
Four randomized trials have shown that screening for AAA is cost-effective to reduce both AAA related mortality by 50% and all-cause
mortality by 3%. These trials have been the reason why screening 65 year-old-men for AAA has been introduced in Sweden.
In this thesis we evaluated different aspects on screening for AAA.
Study I; the aim was to study whether a biological marker (APC PCI complex) may be used as a screening marker for AAA in patients
with peripheral vascular disease without previously known AAA. However, the sensitivity and specificity were both to weak to be used as
a screening marker for AAA in the clinical praxis. Nevertheless, we discovered that the prevalence of AAA was 13% in patients with
peripheral vascular disease.
Study II; the aim was to investigate the impact of socioeconomic status (SES) and demographical aspects on compliance to AAA-
screening and also to evaluate the associations between AAA prevalence and SES. Our results indicated that the prevalence of AAA is
higher in demographic areas with lower SES. The compliance to AAA-screening was also lower in areas with lower SES.
Study III; the aim was to investigate if a collaboration between a professional advertising agency and an academic vascular unit can
result in increased compliance to AAA screening. The results showed that compliance to AAA-screening can be increased significantly
by consulting an advertisng agency.
Study III; the aim was to evaluate if screening is still cost-effectivley in the new era of decreased AAA prevalence, EVAR as the
predominant treatment method and improved medical treatment. By using a Markov model we could show that it is still cost-effective
to screen for AAA even with the aformentioned changes.
In conclusion; Screening for AAA seems justified in the new era of changing prerequisites. However, importance of SES and different
aspects on improving AAA compliance are of great importance and need to be studied further.
Abdominal aortic aneurysm (AAA) is a hideous life threatening disease that most often is asymptomatic until it ruptures. Ruptured
abdominal aortic aneurysm (rAAA) is a painful and serious predicament with a mortality of 80-90%. Half of the patients die before
arriving to hospital, leaving family members in sorrow and shock. In Sweden about 700-1000 patients die each year due to rAAA,
corresponding to 1.5% of all deaths in men.
Four randomized trials have shown that screening for AAA is cost-effective to reduce both AAA related mortality by 50% and all-cause
mortality by 3%. These trials have been the reason why screening 65 year-old-men for AAA has been introduced in Sweden.
In this thesis we evaluated different aspects on screening for AAA.
Study I; the aim was to study whether a biological marker (APC PCI complex) may be used as a screening marker for AAA in patients
with peripheral vascular disease without previously known AAA. However, the sensitivity and specificity were both to weak to be used as
a screening marker for AAA in the clinical praxis. Nevertheless, we discovered that the prevalence of AAA was 13% in patients with
peripheral vascular disease.
Study II; the aim was to investigate the impact of socioeconomic status (SES) and demographical aspects on compliance to AAA-
screening and also to evaluate the associations between AAA prevalence and SES. Our results indicated that the prevalence of AAA is
higher in demographic areas with lower SES. The compliance to AAA-screening was also lower in areas with lower SES.
Study III; the aim was to investigate if a collaboration between a professional advertising agency and an academic vascular unit can
result in increased compliance to AAA screening. The results showed that compliance to AAA-screening can be increased significantly
by consulting an advertisng agency.
Study III; the aim was to evaluate if screening is still cost-effectivley in the new era of decreased AAA prevalence, EVAR as the
predominant treatment method and improved medical treatment. By using a Markov model we could show that it is still cost-effective
to screen for AAA even with the aformentioned changes.
In conclusion; Screening for AAA seems justified in the new era of changing prerequisites. However, importance of SES and different
aspects on improving AAA compliance are of great importance and need to be studied further.
Department/s
Publishing year
2015
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2015:79
Full text
Document type
Dissertation
Publisher
Unit for Clinical Vascular Disease Research
Topic
- Surgery
Keywords
- Abdominal aortic aneurysm
- screening
- biomarkers
- socioeconomic status
Status
Published
Research group
- Vascular Diseases - Clinical Research
Supervisor
- Anders Gottsäter
- Bengt Lindblad
- Jan Holst
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-7619-158-3
Defence date
18 September 2015
Defence time
13:00
Defence place
Lilla Aulan, MFC, Jan Waldenströms gata 2, Skånes universitetssjukhus i Malmö
Opponent
- Håkan Pärsson (Associate Professor)