Personalised nutrition : status and perspectives
Author
Summary, in English
Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations.
Department/s
Publishing year
2007
Language
English
Pages
26-31
Publication/Series
British Journal of Nutrition
Volume
98
Issue
01
Document type
Journal article review
Publisher
Cambridge University Press
Topic
- Nutrition and Dietetics
Keywords
- disease risk
- genotype
- nutrigenetics
- nutritional recommendations
- nutrigenomics
Status
Published
ISBN/ISSN/Other
- ISSN: 1475-2662