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Effect of the electrical currents generated by the intestinal smooth muscle layers on pancreatic enzyme activity: An in vitro study

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Author

  • Marta Dabek
  • Pawel Podgurniak
  • Jose L. Valverde Piedra
  • Sylwia Szymanczyk
  • Rafal Filip
  • Anna Wojtasz-Pajak
  • Eliza Werpachowska
  • Malgorzata Podgurniak
  • Stefan Pierzynowski

Summary, in English

Gut enzymes in the small intestine are exposed to extremely low electrical currents (ELEC) generated by the smooth muscle. In the present study, the in vitro tests were undertaken to evaluate the effect of these electric currents on the activity of the proteolytic pancreatic digestive enzymes. A simulator generating the typical electrical activity of pig gut was used for these studies. The electric current emitted by the simulator was transmitted to the samples, containing enzyme and its substrate, using platinum plate electrodes. All samples were incubated at 37 degrees C for I h. The changes in optical density, corresponding to enzyme activity, in samples stimulated for I h with ELEC was compared with that not exposed to ELEC. The obtained results show that the electrical current with the characteristics of the myoelectrical migrating complex (MMC) has an influence on pancreatic enzyme activity. Increased endopeptidase and reduced exopeptidase activity was noticed in samples treated with ELEC. This observation can be of important as analyzed factors which can alter enzymatic activity of the gut, can thus also affect feed/food digestibility. Bioelectromagnetics 28:275-280, 2007. (c) 2007 Wiley-Liss, Inc.

Department/s

Publishing year

2007

Language

English

Pages

275-280

Publication/Series

Bioelectromagnetics

Volume

28

Issue

4

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Zoology

Keywords

  • enzyme activity
  • myoelectrical activity
  • endogenous electric current

Status

Published

ISBN/ISSN/Other

  • ISSN: 0197-8462